The Patient Protection and Affordable Care Act is the law of the land and will likely continue to be for some time, despite opponents’ best efforts to get it thrown out in court.

But what the law will look like a few years down the line is anybody’s guess. In fact, the landmark legislation has already been changed significantly since it was originally enacted more than five years ago.

Mercy will be the 58th rural hospital to close in the United States since 2010, according to one research program, and many more could soon join the list because of declining reimbursements, growing regulatory burdens and shrinking rural populations that result in an older, sicker pool of patients. The closings have accelerated over the last few years and have hit more midsize hospitals like Mercy, which was licensed for 75 beds, than smaller “critical access” hospitals, which are reimbursed at a higher rate by Medicare.